Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660237
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: NISHIFUJI Koji 東京農工大学, (連合)農学研究科(研究院), 准教授 (20365422)
• Co-Investigator(Kenkyū-buntansha): SHIROTA Kinji 麻布大学, 獣医学部, 教授 (70149322)
• Co-Investigator(Renkei-kenkyūsha): OHYAMA Manabu 慶應義塾大学, 医学部, 准教授 (10255424)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ネスチン

Outline of Final Research Achievements

In this study, we investigated distribution and differentiation potential of nestin-expressing cells in normal skin, cutaneous tumor and wounded skin. The nestin-expressing spindle cells and pericytes are distributed in dermal papilla, as well as dermis surrounding cutaneous epithelial tumor and wounded skin. In addition, we found that keratinocytes in outer root sheath cells, keratoacanthoma and wounded skin are daughter cells of nestin-expressing cells. These findings imply that nestin-expressing spindle cells contribute to keratinocyte proliferation, and some of keratinocytes in hair follicle and cutaneous epithelial tumors consist of daughter cells of the neural crest stem cells.

Free Research Field

獣医学