2014 Fiscal Year Final Research Report
The "structure" and "function" of mammary gland in stress pregnancy
| Project/Area Number |
25660248
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Integrative animal science
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 高血圧妊娠 / 乳腺 / レニン-アンジオテンシン系 / 授乳 / アンジオテンシンII受容体 |
|---|
| Outline of Final Research Achievements |
Angiotensin II (AngII) has critical roles in regulation of blood pressure. We previously generated pregnancy-associated hypertensive (PAH) mice by mating female human angiotensinogen transgenic mice with male human renin transgenic mice. A recent study demonstrated that angiotensin II type I receptor (AT1) is expressed in mammary epithelial cells, however, the role of AngII-AT1 signaling in the development of mammary gland during pregnancy remains unclear. In this study, we analyzed the mammary gland of PAH mice. PAH mice exhibited precocious lobuloalveolar development and increased milk protein and lipid production, indicating that mammary gland development was accelerated in PAH mice. Furthermore, AT1 blocker treatment suppressed acceleration of mammary gland development in PAH mice, while antihypertensive drug hydralazine treatment did not. These data suggest that AngII-AT1 signaling accelerates mammary gland development during pregnancy through hypertension-independent mechanism.
|
| Free Research Field |
分子生物学
|
