2014 Fiscal Year Final Research Report
Establishment of a method for induction of artificial hibernation, and its application to hypothermic therapy in non-hibernators.
| Project/Area Number |
25660249
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIINA Takahiko 岐阜大学, 応用生物科学部, 准教授 (90362178)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 冬眠 / 低体温 / 心臓 / 低温ショックタンパク質 / 麻酔 / 生理学 / 獣医学 |
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| Outline of Final Research Achievements |
The present study was designed to develop a method for inducing hypothermia, which is equivalent to hibernating animals, in non-hibernators, to apply the hypothermic condition as a novel hypothermic therapy. In hamsters, extreme hypothermia with normal heartbeats can be forcibly induced by cooling the animals under isoflurane inhalation and stopping the inhalation when their body temperature was dropped about 25C. Application of the method to rats successfully induced hypothermia without accompanying cardiac arrest. In addition, we examined mechanism underlying cold-tolerant nature of the hamster heart, and found that regulation of cold-shock protein expression may have a beneficial role.
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| Free Research Field |
神経生理学
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