Identification of novel editing factors towards elucidation of molecular mechanism of RNA editing

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660292
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: Nagoya University
• Principal Investigator: SUGITA Mamoru 名古屋大学, 遺伝子実験施設, 教授 (70154474)
• Co-Investigator(Renkei-kenkyūsha): AOKI Setsuyuki 名古屋大学, 大学院情報学研究科, 准教授 (30283469)
• Research Collaborator: ICHINOSE Mizuho ; SUGITA Chieko ; UCHIDA Masato ; NAKAMURA Takahiro
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: RNA編集 / ミトコンドリア / 葉緑体 / ヒメツリガネゴケ / シチジンデアミナーゼ / RNAi / PPRタンパク質

Outline of Final Research Achievements

In plant mitochondria and plastids, C-to-U RNA editing frequently occurs in many transcripts. However, the molecular mechanism of RNA editing remains to be elucidated. In this study, three novel RNA editing factors were identified in the moss Physcomitrella patens. In addition, a C-terminal 39 amino acid region of identified RNA editing factors was clarified to be required for editing site-specific recognition.

Free Research Field

植物オルガネラ遺伝子発現制御