Asymmetric molecular transformation using chiral onium amides

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670002
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: KONDO Yoshinori 東北大学, 薬学研究科(研究院), 教授 (90162122)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Yoshiyuki 東北大学, 大学院薬学研究科, 准教授 (70333797) ; INAMOTO Kiyofumi 武庫川女子大学, 薬学部, 准教授 (30359533) ; KUMADA Kanako 東北大学, 大学院薬学研究科, 助手 (30748504)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: オニウムアミド / キラル / 不斉 / 分子変換 / 脱プロトン化 / 有機触媒 / 複素芳香環 / シンコナアルカロイド

Outline of Final Research Achievements

Onium amides have been used for catalytic functionalization of heteroaromatic compoumds, which amides were generated in situ using a combination of onium fluorides and aminosilanes. Chiral onium amides prepared from chiral ammonium fluorides with aminosilanes or chiral phosophonium fluorides with aminosilanes. Enantioselective transformation of heteroarenes was investigated using these chiral onium amides, .

Free Research Field

有機反応化学