Drug discovery of innovative small molecules with inhibition of RAGE-GAG interaction

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670018
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: KAZUYUKI Sugahara 北海道大学, 先端生命科学研究科(研究院), 名誉教授 (60154449)
• Co-Investigator(Kenkyū-buntansha): MIZUMOTO Shuji 名城大学, 薬学部, 助教 (40443973)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: コンドロイチン硫酸 / RAGE / プロテオグリカン / 癌 / 糖鎖創薬

Outline of Final Research Achievements

Previously, we demonstrated that pulmonary metastasis is initiated by interaction of CS chain on tumor cells with Receptor for Advanced Glycation End-products (RAGE) on lung. The aim of this study was to develop the seeds of new drugs, oligosaccharides, and small molecular compounds. It was established the preparation of oligosaccharides by the hydrolysis of CS-E with a subcritical water microreaction system, and the screening methodology for effective oligosaccharides by inhibition of the interaction of CS-E with RAGE. These observations will provide the seeds of new anti-cancer drug.

Free Research Field

糖鎖生物学