Neural stem cells have directivity characteristics in the cell fate decision.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670037
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Osaka University
• Principal Investigator: KASAI Atsushi 大阪大学, 薬学研究科(研究院), 助教 (40454649)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: miRNA / 神経幹細胞 / セロトニン / noggin / 運命決定

Outline of Final Research Achievements

Neural stem cells have pluripotency to differentiate into a variety of neural cells, such as neuron and glia cells. Here, we showed that noggin treatment to embryonic stem cells changed miRNA expression patterns in neural stem cells differentiated by diverse methods and increased serotonin neuronal differentiation. These findings suggest that pluripotency of neural stem cells may be already assigned the directional differentiation.

Free Research Field

(3) 神経薬理学