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2014 Fiscal Year Final Research Report

Screening study on natural products having effects on histone modification and epigenetic control mechanism

Research Project

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Project/Area Number 25670045
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Natural medicines
Research InstitutionChiba University

Principal Investigator

ISHIBASHI Masami  千葉大学, 薬学研究科(研究院), 教授 (90212927)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsシグナル伝達 / 生理活性 / 薬学 / 生体分子 / 薬学
Outline of Final Research Achievements

This study aims at search for bioactive small molecule from natural resources that have effects on BMI1, which is a key regulatory component of the polycomb repressive complex1 (PRC1) as well as those that act on Wnt and hedgehog signaling pathways, which are known to control the expression of BMI1 molecule. First a cell-based luciferase assay system which assesses the BMI1 promoter activity was constructed, and screening study using this assay system afforded several plant extracts as hit samples. On the other hand, a diterpene from a Plantaginaceous plant and a limonoid from a Meliaceous plant with Wnt signal inhibitory activity were isolated, while a highly oxygenated steroid derivative with hedgehog inhibitory activity was obtained from Solanaceous plant.

Free Research Field

天然物化学

URL: 

Published: 2016-09-02  

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