2014 Fiscal Year Final Research Report
Development of a novel compound and a novel target protein for multi-drug resistant cancer
| Project/Area Number |
25670049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tomonori 慶応義塾大学, 薬学部, 教授
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 多剤耐性 / シクロオキシゲナーゼ / インドール |
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| Outline of Final Research Achievements |
We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug-resistance indicated that NSAIDS modulation of multidrug resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.
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| Free Research Field |
創薬科学
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