Study for the colloidal nanoparticles of drug molecules by fluoro-functionalization

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670055
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: SHIBATA Norio 名古屋工業大学, 工学(系)研究科(研究院), 教授 (40293302)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: フッ素 / フタロシアニン / サブフタロシアニン / 医薬品 / 光線力学的

Outline of Final Research Achievements

Colloidal nanoparticle of pharmaceuticals might have improved stability and sustainability in the body than those of the common solution-state of drugs. We envisaged that the encapsulation of target drugs by capsule-shaped organic molecules with fluorine or fluorinated functional groups at their peri-positions should be a potential strategy to realize this idea. Phthalocyanines and subphthalocyanine known as organic dyes were selected as the templates of capsule molecules, which should be functionalized by fluorinated functional groups. After many attempts, we succeeded the synthesis of fluorinated phthalocyanines, subphthalocyanines and their hybrid compounds. These dyes show unique aggregation-state depend on their solvents. X-Ray crystallographic analysis and/or molecular calculations revealed their capsule-shaped structures. Photodynamic therapy experiments of selected fluorinated dyes were examined and showed interesting biological activities.

Free Research Field

有機フッ素化学