The development of protein delivery system through the cell membrane

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670082
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Showa Pharmaceutical University
• Principal Investigator: KOIZUMI Naoya 昭和薬科大学, 薬学部, 講師 (80433845)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ターゲティング / がん / タンパク質医薬品

Outline of Final Research Achievements

As the cancer tissue is increased, medicine is less likely to reach the central portion of the cancer tissue. In particular, protein pharmaceuticals having a relatively large molecular weight, low arrival rate to the central portion of the cancerous tissue as its size, which decrease therapeutic effect. Therefore, the present study was conducted to develop a new technology to transport efficiently therapeutic protein in deep (center portion) of cancer tissue. As a result, a therapeutic protein using the viral proteins successfully be delivered to deep of cancer tissue. However, from the fact that you've been delivered also to normal tissue as well as cancer tissue, the grant of the only transport available functions in cancer tissue was cited as future challenges.

Free Research Field

薬物ターゲティング