Autophagy is involved in a clearance of anti-cancer agent doxorubicin in the multidrug resistant cancer cell line.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670083
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Nagahama Institute of Bio-Science and Technology
• Principal Investigator: NARA Atsuki 長浜バイオ大学, バイオサイエンス学部, 講師 (60387959)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 薬剤耐性 / オートファジー / ドキソルビシン

Outline of Final Research Achievements

Release of drug from the cancer cells contributes reduction of its cytotoxicity. How are the chemotherapeutic agents that accumulated in the cells released to the extracellular space? In my study, I tried to examine about a direct involvement of autophagy in anti-cancer drug doxorubicin delivery. The study provides a novel insight for an autophagic delivery of doxorubicin from the nucleus to the lysosomes in multidrug resistant cancer cell line.

Free Research Field

細胞生物学