• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Cellular protrusions that transport diverse signaling molecules and the receptors: molecular mechanisms of their formation and their functions in morphogenesis

Research Project

  • PDF
Project/Area Number 25670104
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionChiba University

Principal Investigator

ENDO Takeshi  千葉大学, 理学(系)研究科(研究院), 教授 (30194038)

Co-Investigator(Renkei-kenkyūsha) TAKANO Kazunori  千葉大学, 大学院融合科学研究科, 助教 (60466860)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords細胞間シグナル伝達 / 細胞突起 / シグナル分子 / 受容体 / RhoD
Outline of Final Research Achievements

CyN are unique cellular protrusions participating in efficient intercellular signal transduction of morphogens and FGFs. We found that CyN are formed through RhoD by various growth factors including FGF, TGF-β superfamily proteins, cytokines, GPCR ligands, and Shh. Among these signaling molecules, BMP4, as well as FGFs, activated RhoD, which induced CyN formation. The RhoD activation by BMP4 is likely to be mediated by non-Smad signaling but not by Smad signaling. Furthermore, GTPase activity of dynamin was required for CyN formation. Cells stably expressing LIF formed CyN, suggesting that CyN are involved in ligand transport and secretion by producing cells as well as in ligand-receptor transport by target cells.

Free Research Field

分子細胞生物学

URL: 

Published: 2016-09-02  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi