2014 Fiscal Year Final Research Report
Assessment of temperature compensation of circadian rhythm by using cold-blooded mice
| Project/Area Number |
25670118
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHI Eiichiro 京都大学, 大学院医学研究科, 准教授 (30362528)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 概日リズム / 温度補償性 |
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| Outline of Final Research Achievements |
The period of the circadian rhythm is kept relatively constant over a wide range of temperatures, which means “temperature compensation”. So far, it is impossible to change body temperature of warm-blooded mammals. NRDc deficient mice (KO) that we generated have a feature as so-called “cold-blooded mice”. To evaluate the correlation between environmental temperature and body temperature, we housed KO mice at high temperature (38℃) and low temperature (10℃). Body temperature of KO mice became 38℃ and 35℃, respectively. However, it is difficult to keep these body temperatures for a long period.
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| Free Research Field |
細胞生物学、分子生物学
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