Role of TRPA1 as the front-line sensor to the environmental gas threats

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670121
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kagoshima University
• Principal Investigator: KUWAKI Tomoyuki 鹿児島大学, 医歯(薬)学総合研究科, 教授 (80205260)
• Research Collaborator: TAKAHASHI Nobuaki ; MORI Yasuo ; OOTSUKA Youichirou ; KASHIWADANI Hideki ; INUI Keiichi ; CHEN ChangPing ; KUROKI Chiharu ; YONEMITSU Toru ; KANMURA Yuichi
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 環境有害物質 / 忌避行動 / 睡眠・覚醒 / TRPA1 / 低酸素 / 感覚神経 / 三叉神経 / 呼吸

Outline of Final Research Achievements

I hypothesized that Transient Receptor Potential Ankirin-1, one of the TRP ion channel family proteins, play a role as the front-line sensor to the environmental gas threats including hypoxic and irritating gases to prevent further incorporation of them by inducing arousal, avoidance behavior, and respiratory slowing. An affirmative results were obtained. Furthermore, TRPA1 located in the trigeminal nerve in the nasal cavity was most responsible for the responses.

Free Research Field

環境生理学、神経生理学