Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670124
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Asahikawa Medical College
• Principal Investigator: USHIKUBI Fumitaka 旭川医科大学, 医学部, 教授 (50243035)
• Co-Investigator(Kenkyū-buntansha): YUHKI Koh-ichi 旭川医科大学, 医学部, 准教授 (80302420) ; KASHIWAGI Hitoshi 旭川医科大学, 医学部, 助教 (60510609)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 糖質コルチコイド / プロスタノイド / 心臓

Outline of Final Research Achievements

Recently, glucocorticoid has been reported to up-regulate cardiac prostanoid synthesis. However, the precise mechanism of this regulation remains to be clarified. On the other hand, the prostanoids play an important role in the pathogenesis of acute myocardial infarction and pressure overload-induced cardiac hypertrophy. The aims of this study are to clarify the regulatory action of glucocorticoid on cardiac prostanoid synthesis and its role in the pathogenesis of cardiac diseases. Glucocorticoid induced up-regulation of COX-1 and L-PGDS, the enzymes for prostanoid biosynthesis, and prostanoid receptors FP and EP2 in the heart. Because we established the murine model of adrenal ablation, we would like to examine the pathophysiology of these mice subjected to cardiac infarction or cardiac pressure overload.

Free Research Field

薬理学