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2014 Fiscal Year Final Research Report

In vitro cardiotoxicity assay system using MVP technology

Research Project

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Project/Area Number 25670126
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FURUKAWA Tetsushi  東京医科歯科大学, 難治疾患研究所, 教授 (80251552)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords心毒性 / 動きベクトル
Outline of Final Research Achievements

Cardiotoxicity of drugs is the main cause of drop out from the pipeline and recall from the market. Thus, the development of assay system, especially in vitro assay system in the early stage of drug development, has been strongly required from pharmaceutical companies. Here, we used multi-electrode array (MEA) system and motion vector prediction (MVP) system developed by the Sony coorporation to establish the system to simultaneously assay electrical activity and contractility in cardiomyocytes. We confirmed in human iPS-derived cardiomyocytes that drugs known to possess positive and negative inotropic effects could be reliably assayed. Recently, the cardiotoxicity of anti-cancer drugs has been strongly concerned. We successfully assayed cardiotoxicity of anticancer drugs.

Free Research Field

循環薬理

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Published: 2016-09-02  

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