Mechanism of genomic stability of the naked mole rat

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670148
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Hokkaido University (2014-2015); Keio University (2013)
• Principal Investigator: Miura Kyoko 北海道大学, 遺伝子病制御研究所, 講師 (80583062)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU ATSUSHI 岩手医科大学, いわて東北メディカル・メガバンク機構, 特命教授 (30327655)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ハダカデバネズミ / naked mole rat

Outline of Final Research Achievements

Naked mole-rat (NMR) is one of only two eusocial mammals like ant or bee. NMR’s maximum lifespan exceeds 30 years although their body size is same as mouse. Moreover, these animals have never been observed any spontaneous tumor formation. The purpose of this study is to test whether NMR cells have the resistance to DNA damage or not. We treated the cells with mitomycin C or radiation, and found that NMR cells may have the resistance to acute DNA damage. Furthermore, we generated knock-in ES cells carrying NMR-gene X, which contribute to the DNA damage response, toward the generation of NMR-gene X knock-in mouse.

Free Research Field

分子生物学