2013 Fiscal Year Final Research Report
Roles of Polycomb-group in links between metabolism and cancer
| Project/Area Number |
25670152
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
ISONO Kyoichi 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90323435)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | エネルギー代謝 / ポリコーム群 / 遺伝子制御 / がん |
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| Research Abstract |
Massive proliferation of cancer cells needs energy produced mainly by activating glycolysis. On the other hand, it is thought that elevated activities of Polycomb-group (PcG) proteins are one of causes for tumorigenesis. Understanding them will be helpful for cancer therapies. We have already identified mine metabolic kinases, which might affect PcG functions. This evidence has made us speculate interdependence between energy metabolism and PcG functions in cancer cells. In this study, we addressed this hypothesis by using gene knockdown experiments and co-immunoprecipitation assay, revealing that three of them could have something to do with PcG proteins or their functions. These results are supporting our hypothesis. We therefore believe that this project is worth being investigated continuously, contributing to applied medical science.
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[Journal Article] WIP1, a Homeostatic Regulator of the DNA Damage Response, Is Targeted by HIPK2 for Phosphorylation and Degradation2013
Author(s)
Choi DW, Na W, Kabir MH, Yi E, Kwon S, Yeom J, Ahn JW, Choi HH, Lee Y, Seo KW, Shin MK, Park SH, Yoo HY, Isono K, Koseki H, Kim ST, Lee C, Kwon YK, Choi CY
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Journal Title
Mol Cell
Volume: 51
Pages: 374-385
Peer Reviewed
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