2014 Fiscal Year Final Research Report
The neural circuits underlying the pathophysiologies of schizophrenia
| Project/Area Number |
25670154
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Research Institute, Shiga Medical Center |
|---|
Principal Investigator |
TANIGAKI Kenji 滋賀県立成人病センター(研究所), その他部局等, 専門研究員 (70362473)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 統合失調症 / 神経回路網 / 22q11欠損症候群 / copy number variation / Cre / 動物モデル / レンチウイルス |
|---|
| Outline of Final Research Achievements |
22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this disorder develop schizophrenia. 22q11-deleted region is conserved in mouse cromosome16, which facilitated a mouse model of 22q11 deletion syndrome. We performed neurodevelopmental analysis of this model mice, and found developmental abnormalities in the hippocampal dentate gyrus and the cortical interneurons. Our data demonstrated that these developmental abnormalities are caused by hemizygous deletion of Dgcr8, one of the genes in the 22q11-deleted region.
|
| Free Research Field |
分子医学
|
