2014 Fiscal Year Final Research Report
The investigation of the role of bone in the regulation of neuron.
| Project/Area Number |
25670161
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOGA Takako 東京大学, 医学(系)研究科(研究院), 助教 (90451905)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 骨芽細胞 / 生理活性 / 神経細胞 / 突起伸長 |
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| Outline of Final Research Achievements |
The osteoblast-culture medium were confirmed to have the effect of induction of neurite elongation of PC-12 cell lines. Such putative molecules in the osteoblast-culture medium were purified and analyses by MS protein analyzation. Numerous secreted proteins were identified, but 9 of these molecules are known to be regulators of neurite outgrouth. Therefore, these 9 molecules are analyzed whethre these molecules have such effect by gain-of-function or loss-of-function experiments.
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| Free Research Field |
骨免疫学
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