2014 Fiscal Year Final Research Report
Proteasome genes and immunologic disorders
| Project/Area Number |
25670185
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KASAHARA Masanori 北海道大学, 医学(系)研究科(研究院), 教授 (30241318)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | プロテアソーム / 胸腺 |
|---|
| Outline of Final Research Achievements |
Proteasomes are multi-subunit proteases responsible for the production of peptides presented by major histocompatibility complex class I molecules. In this project, we investigated the role of proteasomes in the thymic selection of CD8+ T cells using mice genetically modified for the β5 family of proteasome subunits. We also investigated the expression of the thymoproteasome-specific β5t subunit in the thymus in patients with Down syndrome.
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| Free Research Field |
病理学
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