Identification of an internal TLR7 ligand related to the onset of Systemic Lupus Erythematosus

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670189
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: SAITOH Shin-Ichiroh 東京大学, 医科学研究所, 助教 (90361625)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 全身性エリトマトーデス / Toll-like receptor 7 / pristane / 内在性リガンド / SLEモデルマウス

Outline of Final Research Achievements

We revealed that a small G protein we identified play a role for type 1 Interferon expression via TLR7 activation. Because it is reported that both TLR7 and type 1 Interferon are related to Systemic Lupus Erythematosus (SLE). We analyzed small G protein deficient SLE model mice, MRL-lpr. As a result, they could not be found the onset of SLE. This result is more significantly inhibited than TLR7 deficient or type 1 interferon receptor deficient MRL-lpr mice. These results indicate that small G protein we identified has an important role for the onset of SLE.

Free Research Field

免疫学