Identification of trigger factor for the differentiation of Toxoplasma bradyzoite

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670199
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: KATO Kentaro 帯広畜産大学, 原虫病研究センター, 准教授 (30401178)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: トキソプラズマ / 潜伏感染 / 全ゲノム遺伝子解析 / 薬剤耐性

Outline of Final Research Achievements

We succeeded in the detection of parasite factor associated with dormant differentiation by the whole genome sequence analyses. We established the experimental system that Toxoplasma cysts can be formed in mice brain. The effects of drugs were analyzed using this system. The recombinant parasite was manufactured which have the luminescent gene downstream of the promoter of gene associated with dormant differentiation. The drug screening system which selects the inhibitors of dormant differentiation by the luminescent activity was established.

Free Research Field

寄生虫学