2014 Fiscal Year Final Research Report
Elucidation of pathological process of schistosomiasis using multiphoton fluorescence microscopy and PET/SPECT
| Project/Area Number |
25670204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORO Kazuyo 独立行政法人理化学研究所, 免疫細胞システム研究グループ, 上級研究員 (90468489)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 住血吸虫 / 肉芽形成 / ナチュラルヘルパー細胞 / NH cell / 可視化 / PET-SPECT / 多光子顕微鏡 |
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| Outline of Final Research Achievements |
Recently, natural helper cell (NH cell) was discovered（Moro K, Nature 2010）. We detected the accumulation of NH cells in the liver of mice, which showed the peak 3 days after inoculation of Schistosoma mansoni 2000 eggs. The signal detected in the liver by PET-SPECT increased when NH cells shows their peak in the liver. However so as to visualize process of granuloma formation around Schistosoma egg, both improvement of method and increase of resolution are required.
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| Free Research Field |
寄生虫学
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