Establishment of basic research system of bacterial infections in common marmoset

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670207
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Hirosaki University
• Principal Investigator: NAKANE AKIO 弘前大学, 医学(系)研究科(研究院), 教授 (30164239)
• Co-Investigator(Renkei-kenkyūsha): NARITA KOUJI 弘前大学, 医学(系)研究科(研究院), 助教 (30419220) ; ONO HISAYA 弘前大学, 医学(系)研究科(研究院), 助教 (80704569)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感染症 / 霊長類 / 毒素 / 細菌 / 嘔吐 / 下痢 / 肥満細胞 / セロトニン

Outline of Final Research Achievements

Experimental animals including mice and rats are usually used in research on medical science. However, we should recognize that experimental data from these animals may disparate in humans. We investigated availability of a small rodent, common marmoset, in research on bacterial infections containing toxins produced from Staphylococcus aureus.
Oral administration of staphylococcal enterotoxins (SEs) induced emesis in common marmosets. Moreover, we found that SEs induced diarrhea and other staphylococcal toxins can induce emesis in common marmosets. Therefore, common marmoset is a useful animal model for research on bacterial infections.

Free Research Field

医歯薬学