Dual effector BspR that functions in Bordetella and host cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670215
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Kitasato University
• Principal Investigator: ABE Akio 北里大学, 感染制御科学府, 教授 (50184205)
• Co-Investigator(Renkei-kenkyūsha): KUWAE Asaomi 北里大学, 感染制御科学府, 准教授 (60337996) ; KITADOKORO Kengo 京都工芸繊維大学, 工芸科学研究科, 准教授 (60283587)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 百日咳菌 / 気管支敗血症菌 / ボルデテラ属 / III型分泌装置 / エフェクター / BspR / 核移行

Outline of Final Research Achievements

Many genes are regulated by transcriptional regulator, BspR, in Bordetella pertussis and its related strain, B. bronchiseptica. In this study, we demonstrated that BspR is translocated into the host cells via a type III secretion system (T3SS). Interestingly, BspR N-terminus is involved in the T3SS-mediated translocation and the nuclear transport. In this study, we revealed that BspR is not only a bacterial regulator, but also functions as a translocated effector into the host nucleus. Thus, we propose that BspR has an ability for a dual-effector that functions in bacteria and the host cells.

Free Research Field

医歯薬学