Development of a device for the surveillance of the mutated highly pathogenic influenza viruses which acquired human-type receptor binding specificity

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670219
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Chubu University
• Principal Investigator: SUZUKI Yasuo 中部大学, 生命健康科学部, 教授 (00046278)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: インフルエンザウイルス / 高病原性鳥インフルエンザウイルス / デバイス / ヒト / 監視 / 鳥 / 変異 / シアル酸

Outline of Final Research Achievements

We developed a Novel Immunochromatographic device for Easy-to-use detection of highly pathogenic avian Influenza viruses (H5N1) with acquired human-type receptor binding specificity. This device is non-invasive for human and animal, light (less than 5gram), small (less than 15cm) and can be completed in 30min and do not require special equipment or skills, thereby avoiding some disadvantages of current methods (ELISA) for analyzing influenza virus receptor binding specificity. We confirmed its practicability using native virus isolated in Egypt, Vietnam and Indonesia. The device developed in this study can be used for the international surveillance system for human adapted H5N1 mutants in the field.

Free Research Field

ウイルス学、生化学