Analysis of group 2 innate lymphoid cells in colonic lamina propria

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670237
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ATARASHI Koji 独立行政法人理化学研究所, 統合生命医科学研究センター, 客員研究員 (60546787)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 自然リンパ球 / IL-4 / ビタミン

Outline of Final Research Achievements

Innate lymphoid cells (ILCs) are newly described immune lymphoid cells but do not express antigen-specific receptors. ILC type 2 (ILC2) cells have important functions in innate immune responses to helminth infection and in the regulation of allergic inflammation in the lung. ILC2 cells are abundant in colonic lamina propria, however, the regulatory mechanisms of the development and the role of ILC2 cells in the intestine are poorly understood. We identified that gut ILC2 expressed high level of Il4, H2-Ab1 (MHC class II) and Apoe compared with lung ILC2. We also discovered Il4 expression in gut ILC2 is dependent on dietary vitamin B1. These results indicate that gut ILC2 exhibit unique development programs and functions.

Free Research Field

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