Development of antiviral agents targeting ATP-mediated excision

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670255
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Tohoku University
• Principal Investigator: Kodama Eiichi 東北大学, 医学(系)研究科(研究院), 講師 (50271151)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HIV / 薬物相互作用 / 耐性 / 核酸誘導体

Outline of Final Research Achievements

In this study, we tried to expand our findings of ATP-medicated nucleotide excision inhibition, to biochemical, pharmacological, and structural aspects of DNA polymerases, via HIV reverse transcriptase as a model enzyme. We have established a novel assay system and screened over 5000 chemical compounds developed in the Tohoku University. Employing the identified several hits, structure-activity relation analysis is now in progress. In addition, we demonstrated that inhibitors for HIV reverse transcriptase appear to be experimentally suitable candidate to control differention process of mouse oocyte. Here we demonstrate that antiviral agents are useful for wide-range chemical biology tools as well as medical purpose.

Free Research Field

ウイルス学