Multidisciplinary modificomics to search for novel and early markers to detect hepatobiliary cancers

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670266
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Chiba University
• Principal Investigator: NOMURA Fumio 千葉大学, 医学(系)研究科(研究院), 教授 (80164739)
• Co-Investigator(Kenkyū-buntansha): SAWAI Setsu 千葉大学, 大学院医学研究院, 助教 (10400962) ; SATOH Mamoru 千葉大学, 医学部附属病院, 寄附研究部門教員 (20401002) ; KODERA Yoshio 北里大学, 理学部, 准教授 (60265733) ; NISHIMURA Motoi 千葉大学, 医学部附属病院, 講師 (80400969)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 蛋白質 / プロテオーム / 癌 / 臨床 / 検査医学

Outline of Final Research Achievements

By comprehensive glycoproteomics, we successfully detected and identified novel protein biomarker for excessive drinking. Alterations of this protein were not as a result of liver injury, but by excessive drinking per se. Interestingly, the changes were seen in non-responders to the conventional markers for drinking. We are planning to conduct more comprehensive analyses to detect cancer specific post-translational protein modifications including phosphorylation and ubiquitination.

Free Research Field

医歯薬学