Search of the predictive diagnosis marker of the Chlamydia infection, using a pathological experiment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670278
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Juntendo University
• Principal Investigator: NAKAMURA Shinji 順天堂大学, 医学(系)研究科(研究院), 助教 (40207882)
• Co-Investigator(Kenkyū-buntansha): MATSUO Junji 北海道大学, 保健科学研究院, 講師 (50359486) ; ISHIZU Akihiro 北海道大学, 保健科学研究院, 教授 (60321957)
• Research Collaborator: YAMAGUCHI Hiroyuki 北海道大学, 保健科学研究院, 教授 (40221650) ; ITO Shin
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: クラミジア / 性感染症 / インターロイキン１ / インターロイキン１レセプターアンタゴニスト / プロスタグランジンE2

Outline of Final Research Achievements

Chlamydia trachomatis is the most common sexually transmitted pathogen that the approximately 10% of infection are occurred. Leaving the chlamydia infection untreated, leading to complication such as tubal obstruction and fibrosis in part infected person is known, but the reason is unclear. In this study, we investigated the expression of inflammatory mediators including IL-1, IL-Ra, IL-6 and PGE2 to find a cause of complications, especially fibrosis by chlamydial infections. The positive cells of IL-1, IL-1Ra, and PGE2 were appeared in interstitial infiltrating cells, but there were no signification differences between infected patients with chlamydial and not infected patients. However, in chlamydia infected patient, squamous epithelium and columnar epithelium epithelium of the cervix. and glandular epithelia was celled IL-1 alpha and strong expressions of PGE2. The results suggest that PGE2 plays an important role in the precipitating factor of complication by chlamydia infection.

Free Research Field

病理学