Development of Diagnostics for Sarcopenia with Secretary Neurosynaptic markers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670281
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: SHIBASKI Futoshi 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 参事研究員 (90300954)
• Co-Investigator(Renkei-kenkyūsha): KAJIWARA Naoki 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (70453917) ; NOMURA Namiko 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野・主任基盤技術研究, 職員 (50599694)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 筋萎縮 / サルコペニア / 診断

Outline of Final Research Achievements

The early diagnosis for Sarcopenia is an urgent need for preventing irreversible muscle atrophy and for proper treatment. We succeeded in developing high sensitive multiple simultaneous Tag (MUSTag) method using specific biomarker (Protein A) for sarcopenia. In this assay, the sensitivity was calculated as 16 pg/mL (R2≧0.95) and 0.6 pg/mL (3×S.D.) in the healthy volunteer, the range is less than 300 pg/ml, but the values were measured from 500-4,800 pg/ml in patients of sarcopenia.
These results suggested the following possibilities; (1) the concentration of serum protein A shows the tendency of increase in the condition in which anabolic metabolism is promoted in the normal muscle volume. (2) in the contrast, the concentration does the tendency of decrease in the condition in which catabolic metabolism is promoted in such as inflammation and enhancement of the metabolism.

Free Research Field

分子細胞生物学