Visceral fat, ectopic fat depots, and future adiponectin and leptin levels

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670300
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Osaka City University
• Principal Investigator: HAYASHI Tomoshige 大阪市立大学, 医学(系)研究科(研究院), 准教授 (10381980)
• Co-Investigator(Kenkyū-buntansha): SATO Kyoko 大阪市立大学, 医学(系)研究科(研究院), 講師 (00381989) ; UEHARA Shinichiro 大阪市立大学, 医学(系)研究科(研究院), 助教 (00628696) ; ENDO Ginji 大阪市立大学, 医学(系)研究科(研究院), 教授 (20160393)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: アディポネクチン / レプチン / 内臓脂肪

Outline of Final Research Achievements

Adiponectin and leptin have been reported to be associated with cardiometabolic diseases. However it is not known which fat distribution is prospectively associated with future levels of adiponectin and leptin. Study subjects were 319 non-diabetic men and women who were followed for about 6 years. Intra-abdominal fat area, not abdominal subcutaneous fat area, was associated with future adiponectin level after adjusted for age and gender. For ectopic fat, fat in liver, not thigh muscle fat, was associated with future adiponectin level after adjusted for age and gender. On the other hand, both intra-abdominal fat area and abdominal subcutaneous fat area were independently associated with future leptin level after adjusted for age and gender. For ectopic fat, both fat in liver and thigh muscle fat were independently associated with future leptin levels after adjusted for age and gender.

Free Research Field

糖尿病の疫学、内臓脂肪の疫学、米国在住日系人の疫学、生活習慣病の疫学