2013 Fiscal Year Final Research Report
A novel epidemiological approach for primary prevention with metabolomics
| Project/Area Number |
25670303
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Kazutaka 慶應義塾大学, 政策・メディア研究科, 特任助教 (10466732)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
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| Research Collaborator |
KURIHARA Ayako 慶應義塾大学, 医学部, 教授
HARADA Sei 慶應義塾大学, 医学部, 大学院生
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | メタボローム / 疫学 / バイオマーカー / 予防医学 |
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| Research Abstract |
In this project, we developed metabolomics methodology for epidemiological setting both for CE-MS (polar) and LC-MS (lipids). In the statistical analysis, the association between health-related life style factors such as physical activity, alcohol drinking, diet intake and risk factors of non-communicable diseases including hepatopathy, hypertension, metabolic syndrome. As a result, various polar metabolites determined by CE-MS were determined with relation to alcohol drinking, hypertension, and physical activity. Branched-chain amino acids, leucine, isoleucine and valine, were significantly associated with degree of physical activity or clustering of metabolic syndrome. Further follow-up study is needed to elucidate whether these metabolites can be used for preventive biomarkers.
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[Presentation] Accumulation of metabolic syndrome risk factors and plasma amino acids and their related metabolites : Tsuruoka Metabolomic Cohort Study2014
Author(s)
Toru Takebayashi, Sei Harada, Ayako Kurihara, Miki Akiyama, Tomonori Okamura, Yuji Nishiwaki, Taichiro Tanaka, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita
Organizer
10th Annual Meeting of Metabolomics Society
Place of Presentation
Tsuruoka
Year and Date
20140623-26
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[Presentation] Metabolomic profiling reveals novel biomarkers of alcohol-induced hypertension in community-dwelling men : Tsuruoka metabolomic study2014
Author(s)
Sei Harada, Toru Takebayashi, Ayako Kurihara, Miki Akiyama, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita
Organizer
10th Annual Meeting of Metabolomics Society
Place of Presentation
Tsuruoka
Year and Date
20140623-26
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