2015 Fiscal Year Final Research Report
A Mendelian randomization approach for the identification of causal association in lifestyle disease
| Project/Area Number |
25670306
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
Une Hiroshi 福岡大学, 医学部, 教授 (40122676)
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| Co-Investigator(Kenkyū-buntansha) |
IMATOH Takuya 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官 (20368989)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 遺伝疫学 / 遺伝子多型 / 生活習慣病 / 疫学 |
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| Outline of Final Research Achievements |
We evaluated genetic polymorphisms affecting exposure, such as lifestyle factors and carried out a Mendelian randomization study to elucidate the causal associations. Aldehyde dehydrogenase 2 SNP rs671 was strongly related to alcohol consumption. Therefore Mendelian randomization study that used rs671 SNP as an instrumental variable was conducted. As a result, there are significant association between LDL cholesterol or blood pressure and alcohol consumption. However, we did not find the association between alcohol consumption and triglyceride or haemoglobin A1c which is an index of diabetes mellitus.
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| Free Research Field |
衛生学
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