Towards realization of molecular-targeting cancer prevention; an attempt to develop safe and effective juice for cancer chemoprevention

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670321
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MASUDA Mitsuharu 京都府立医科大学, 医学(系)研究科(研究院), 博士研究員 (10305568)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Hideki 京都府立医科大学, 医学研究科, 特任教授 (30351795)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 癌予防 / 大腸癌 / 天然物

Outline of Final Research Achievements

We evaluated the effects of a variety of natural fruit juices on inhibitory activity of cellular proliferation by reactivating RB function and anti-inflammatory ability based on the concept of “molecular-targeting cancer prevention” to prevent colon cancer.
As the results, a part of fruit juices showed growth-inhibitory activity by G1-phase arrest with reactivation of RB protein. Moreover, several juices also showed anti-inflammatory effects. However, most of juices did not show these effects. We would like to find the more ideal juices for “molecular-targeting cancer prevention”.

Free Research Field

がん予防