2015 Fiscal Year Final Research Report
Determinants of endotoxin levels in suspended particles and their associations with asthma
| Project/Area Number |
25670327
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTANI Naruhito 兵庫医科大学, 医学部, 助教 (10561772)
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| Research Collaborator |
YODA Yoshiko 兵庫医科大学, 医学部, 助教 (80748434)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | エンドトキシン / 微小粒子状物質 / 粗大粒子 / 喘息 / アレルギー / 生活環境 / 空気清浄機 / ペット |
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| Outline of Final Research Achievements |
The endotoxin levels in indoor fine particles (PM2.5) and coarse particles (PM10-2.5) were correlated with the levels in outdoor respective particles. The levels were higher in higher in homes using tatami or carpet for floor than in homes of wooden flooring. The endotoxin levels in indoor PM2.5 were also higher in homes with pets, and lower in homes using air purifier.
The increase in endotoxin levels in PM2.5 and PM10-2.5 were associated with significant decrease in PEF and FEV1 among subjects with wheezing after exercise. On the other hand, among subjects without wheezing, no association between endotoxin levels and pulmonary function was observed.
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| Free Research Field |
環境疫学
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