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2014 Fiscal Year Final Research Report

The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis

Research Project

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Project/Area Number 25670365
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

OKAZAKI Sachiko  東京大学, 医学部附属病院, 病院診療医 (30648720)

Co-Investigator(Renkei-kenkyūsha) OKAZAKI Hiroaki  東京大学, 医学部附属病院, 助教 (80610211)
TAKANASHI Mikio  東京大学, 医学部附属病院, 特任助教 (70610799)
TAKASE Satoru  東京大学, 医学部附属病院, 助教 (80508094)
KUBOTA Midori  東京大学, 保健・健康推進本部, 助教 (20383804)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsコレステロール / リパーゼ / 非アルコール性脂肪性肝炎
Outline of Final Research Achievements

Fatty liver has been recognized not only as a complication of metabolic syndrome but also as a causative factor of steatohepatitis, liver cirrhosis and hepatocellular carcinoma. However, the mechanism how fatty liver progresses to steatohepatitis is not fully understood. Our study was aimed at elucidating the role of lipases in fatty liver and suggested that increased hydrolysis of cholesterol ester and production of free cholesterol in liver may promote inflammation in fatty liver. The exact molecular mechanism is under further investigation.

Free Research Field

医歯薬学

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Published: 2016-06-03  

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