2014 Fiscal Year Final Research Report
The development of the disease model using humanized intestine in mice.
| Project/Area Number |
25670367
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
WATANABE Mamoru 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10175127)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tetsuya 東京医科歯科大学, 医歯学総合研究科, 教授 (70265809)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ヒト化マウス / 大腸移植 / 移植モデル / 発癌モデル |
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| Outline of Final Research Achievements |
The establishment of the animal model that reflects the pathogenesis and the prediction to the therapy for the intestinal bowel disease and colon cancer has been required. In this study, we therefore aimed to establish the mice model, which has humanized intestine by developing our original technic “the method for the plantation of the primary intestinal epithelial cells to the colon”.
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| Free Research Field |
消化器病学
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