2014 Fiscal Year Final Research Report
Enhancing effect of retinoids on anti-cancerous drugs by regulating intracellular molecules
| Project/Area Number |
25670368
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tottori University |
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Principal Investigator |
SHIOTA Goshi 鳥取大学, 医学(系)研究科(研究院), 教授 (70263457)
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| Co-Investigator(Kenkyū-buntansha) |
KANKI Keita 鳥取大学, 大学院医学系研究科, 助教 (10516876)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | レチノイド / 肝細胞癌 / 抗腫瘍効果 / 作用増強 / AMPK |
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| Outline of Final Research Achievements |
All-trans retinoic acid (ATRA) enhanced the antitumorous effects of five anti-cancerous drugs such as 5-FU, cisplatin, sorafenib, mitomycin C, and adriamycin. The effect of ATRA on sorafenib is related to activation of AMPK, decreased production of ATP, suppression of glycolysis, induction of Bax, apoptosis induction, activation of p38 and JNK, and translocation of Bax to mitochondria.
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| Free Research Field |
肝臓学
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