2013 Fiscal Year Final Research Report
Development of novel preventive strategy for post-infarct cardiac rupture via the regulation of inflammatory process by the activation of natural killer T cells
| Project/Area Number |
25670378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
TSUTSUI Hiroyuki 北海道大学, 医学(系)研究科(研究院), 教授 (70264017)
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| Co-Investigator(Kenkyū-buntansha) |
KINUGAWA Shintaro 北海道大学, 大学院医学研究科, 講師 (60399871)
ISHIMORI Naoki 北海道大学, 大学院医学研究科, 助教 (70399848)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 急性心筋梗塞 / 心破裂 / 炎症性サイトカイン / ナチュラルキラーT細胞 / α-ガラクトシルセラミド |
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| Research Abstract |
Myocardial infarction (MI) leads to the development of cardiac rupture as well as heart failure, both of which are the major causes of death in post-MI patients. Chronic tissue inflammation plays an important role in the pathological process of post-MI left ventricular remodeling as well as cardiac rupture. Invariant natural killer T (iNKT) cells orchestrate tissue inflammation via regulating the production of various cytokines. The activation of iNKT cells by alpha-galactosylceramide (alpha-GC), which specifically activates iNKT cells, could be beneficial to protect the heart from acute ischemic injury.
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[Journal Article] Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome2013
Author(s)
Yokota T, Kinugawa S, Yamato M, Hirabayashi K, Suga T, Takada S, Harada K, Morita N, Oyama-Manabe N, Kikuchi Y, Okita K, Tsutsui H
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Journal Title
Diabetes Care
Volume: 36(5)
Pages: 1341-1346
DOI
Peer Reviewed
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[Journal Article] Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice2013
Author(s)
Homma T, Kinugawa S, Takahashi M, Sobirin MA, Saito A, Fukushima A, Suga T, Takada S, Kadoguchi T, Masaki Y, Furihata T, Taniguchi M, Nakayama T, Ishimori N, Iwabuchi K, Tsutsui H
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Journal Title
J Mol Cell Cardiol
Volume: 62
Pages: 179-188
DOI
Peer Reviewed
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[Journal Article] Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice2013
Author(s)
Takada S, Kinugawa S, Hirabayashi K, Suga T, Yokota T, Takahashi M, Fukushima A, Homma T, Ono T, Sobirin MA, Masaki Y, Mizushima W, Kadoguchi T, Okita K, Tsutsui H
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Journal Title
J Appl Physiol
Volume: 114(7)
Pages: 844-857
DOI
Peer Reviewed
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[Journal Article] Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure2013
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Abe T, Suga T, Takada S, Kadoguchi T, Katsuyama R, Oba K, Okita K, Tsutsui H
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Journal Title
Int J Cardiol
Volume: 168(5)
Pages: e142-4
DOI
Peer Reviewed
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[Journal Article] Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure2013
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Abe T, Suga T, Takada S, Kadoguchi T, Okita K, Matsushima S, Tsutsui H
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Journal Title
Int J Cardiol
Volume: 168(4)
Pages: 4313-4314
DOI
Peer Reviewed
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