2013 Fiscal Year Final Research Report
Novel humoral factors regulating epigenomic status
| Project/Area Number |
25670384
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMASHITA Jun 京都大学, iPS細胞研究所, 教授 (50335288)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 発生分化 / 分子心臓学 |
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| Research Abstract |
This study aimed at identification of novel humoral factors that regulate epigenomic status. Following items were investigated; 1) Involvement of adrenomedullin in differentiation and adult physiology. 2) Investigation of novel factors regulating epigenome through PKA signaling. 3) Significance and functions of the identified factors. We succeeded in showing the involvement of AM in the regulation of differentiation timing from embryonic stem cells. We further identified one novel factor that also regulates differentiation timing and epigenomic status. Currently, we are analyzing functions of the factor in the adult mice.
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[Journal Article] Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells2013
Author(s)
Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK.
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Journal Title
Circulation Cardiovascular Genetics
Volume: 6巻
Pages: 624-633
DOI
Peer Reviewed
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