Identifying a factor contributing to gender difference in familial dilated cardiomyopathy

2013 Fiscal Year Final Research Report

• Project/Area Number: 25670393
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Nara Medical University
• Principal Investigator: SAITO Yoshihiko 奈良県立医科大学, 医学部, 教授 (30250260)
• Co-Investigator(Kenkyū-buntansha): 尾上 健児 (90510173)
• Research Collaborator: 木村 彰方 (60161551) ; 瀬藤 光利 (20302664) ; 重信 秀治 (30399555)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Keywords: 循環器・高血圧 / 性差

Research Abstract

Gender difference is well known in cardiovascular disorder. Prevalence of ischemic heart disease is lower in female, or the age at risk of heart failure is higher in female. In this study, we tried to unveil the mechanism of gender difference in cardiovascular disease.
At first, we analyzed gene mutation in patients with familial dilated cardiomyopathy, and found a mutation in a gene which codes inner nucleus membrane protein, lamin. Next, we focused on sex hormone, and found that androgen receptor accumulated in nucleus of cardiomyocyte only in those who had the mutation. Currently we're still continuing to seek the mechanism of gender difference by utilizing lamin knock out mice. We would like to contribute to the progression of cardiovascular field by studying this gender difference issue more in detail.

Research Products

• [Journal Article] Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations (2013)
  • Author(s): Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A.
  • Journal Title: Cardiovasc Res Pages: 382-394
• [Journal Article] Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance : a feasibility study (2013)
  • Author(s): Okayama S, Nakano T, Uemura S, Fujimoto S, omekawa S, Watanabe M, Nakajima T, Saito Y.
  • Journal Title: J Cardiovasc Magn Reson Pages: 87-92
• [Journal Article] Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy (2013)
  • Author(s): Okayama S, Uemura S, Saito Y.
  • Journal Title: Int J Cardiol Pages: 43-45
• [Presentation] Molecular Mechanism of Gender Difference in Heart Failure Caused by Lamin A/C Mutations (2014)
  • Author(s): Kimura A, Arimura T, Onoue K, Ishikawa T, Saito Y.
  • Organizer: 日本循環器学会
  • Place of Presentation: 東京
  • Year and Date: 20140321-23
• [Presentation] Worsening of Renal Function after One Year, Not During Hospitalization, is Stronger Predictor of Prognosis in Patients With ADHF (2013)
  • Author(s): Ueda T, Kawakami R, Sugawara Y, Matsumoto T, Okada S, Soeda T, Okayama S, Somekawa S, Takeda Y, Watanabe M, Kawata H, Uemura S, Saito Y.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Dallas, USA
  • Year and Date: 20131116-20
• [Presentation] Uremic Toxin Aggravates Atherosclerosis by Suppression of Endothelial Soluble Flt-1 Production in CKD (2013)
  • Author(s): Takeda Y, Uemura S, Matsui M, Matsumoto T, Seno A, Okada S, Nishida T, Soeda T, Okayama S, Somekawa S, Watanabe M, Kawata H, Kawakami R, Saito Y.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Dallas, USA
  • Year and Date: 20131116-20
• [Remarks]
  • URL: http://www.naramed-u.ac.jp/~1int/