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2013 Fiscal Year Final Research Report

Cellular mechanism of cardio-adrenal interaction

Research Project

  • PDF
Project/Area Number 25670396
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cardiovascular medicine
Research InstitutionKeio University

Principal Investigator

SANO Motoaki  慶應義塾大学, 医学部, 准教授 (30265798)

Project Period (FY) 2013-04-01 – 2014-03-31
Keywords循環器・高血圧 / 細胞・組織 / 分析科学
Research Abstract

Chronic salt overload in Dahl-salt sensitive rats stimulates aldosterone production via local activation of renin-angiotensin system (RAS). Beta3-adrenergic receptor was highly upregulated concomitant with the progression of cardio-renal injury. Adrenal glands became hypoxic as cardio-renal injury progress and both hypoxia induced the expression of beta3-adrenergic receptor via HIF activation in adrenocortical cells. Macrophages were infiltrated in the adrenal cortex in rats with cardio-renal injury and macrophage ablation reduced aldosterone production. Co-culture with macrophages or a supernatant of macrophages stimulated CYP11B2 expression in adrenocortical cells. Acquisition of catecholamine-responsiveness via the induction of beta3-adrenergic receptor under tissue ischemic and crosstalk between macrophages and adrenocortical cells accounts for the RAS-independent aldosterone production associated with cardio-renal injury.

  • Research Products

    (4 results)

All 2013

All Presentation (3 results) Book (1 results)

  • [Presentation] The Unexpected Mechanism of Aldosterone Production in Salt-sensitive Dahl rats with Heart Failure.2013

    • Author(s)
      Kentaro Ito, Fumiko Mitani, Shintaro Morizane , Tomohiro Matsuhashi, Yoshinori Katsumata, Xiaoxiang Yan, Tsunehisa Yamamoto, Nobuhito Goda, Keiichi Fukuda, Motoaki Sano
    • Organizer
      International Symposium for Aldosterone andRelated Substances in Hypertension (Poster)
    • Place of Presentation
      Sendai
    • Year and Date
      20130427-28
  • [Presentation] The Unexpected Mechanism of Aldosterone Production in Salt-sensitive Dahl rats with Heart Failure2013

    • Author(s)
      Kentaro Ito, Fumiko Mitani, Shintaro Morizane, Tomohiro Matsuhashi, Yoshinori Katsumata, Xiaoxiang Yan, Tsunehisa Yamamoto, Nobuhito Goda, Keiichi Fukuda, Motoaki Sano
    • Organizer
      ISHR
    • Place of Presentation
      San Diego, USA (La Valencia Hotel)
    • Year and Date
      2013-06-29
  • [Presentation] Emergence of β3-adrenergic Receptor and Macrophage Infiltration in the Adrenal Glands Contributed to the Unfavorable Aldosterone Production in Heart Failure2013

    • Author(s)
      Kentaro Ito, Fumiko Mitani, Shintaro Morizane , Tomohiro Matsuhashi, Yoshinori Katsumata, Xiaoxiang Yan, Tsunehisa Yamamoto, Nobuhito Goda, Keiichi Fukuda, Motoaki Sano
    • Organizer
      The 6th IAFJ Award Finalists' Oral Presentation 5th International Aldosterone Forum Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-04-21
  • [Book] 心不全とアルドステロン、コルチゾ―ル CIRCULATION Up-to-Date誌、8巻4号の Current Review(Heart Failure編)2013

    • Author(s)
      佐野元昭、松橋智弘、勝俣良紀、伊藤健太郎
    • Total Pages
      56(420)-61(425)
    • Publisher
      メディカ

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Published: 2015-06-25   Modified: 2015-08-12  

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