Development of a novel renal functional evaluation strategy by positron emission tomography imaging in human.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670405
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Ito Sadayoshi 東北大学, 医学(系)研究科(研究院), 教授 (40271613)
• Co-Investigator(Kenkyū-buntansha): IWATA REN 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038) ; TASHIRO MANABU 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477) ; MORI TAKEFUMI 東北大学, 大学院医学系研究科, 准教授 (40375001) ; OHSAKI YUSUKE 東北大学, 大学院医学系研究科, 助教 (40509212)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腎臓 / 画像評価法 / 腎機能 / ポジトロン断層法(PET) / 腎不全 / 局所血流評価 / イメージング

Outline of Final Research Achievements

In this study, we tried to develop a novel renal functional evaluation strategy by positron emission tomography imaging in human. [15O]H2O-PET images of healthy volunteers and end stage renal disease (ESRD) patients were captured. Renal local blood flow did not changed in the dehydrated condition compared to the hydrated condition. However, the renal local blood flow was significantly decreased in ESRD patients compared to healthy volunteer. These findings indicate that [15O]H2O-PET imaging could be one of the tool of evaluation for the renal medulla functions.

Free Research Field

腎臓内科学