2014 Fiscal Year Final Research Report
Mitophagy and acute kidney injury
Project/Area Number |
25670412
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Kochi University |
Principal Investigator |
TERADA Yoshio 高知大学, 教育研究部医療学系, 教授 (30251531)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | オートファジー / 尿細管 / 急性腎障害 / 虚血 / 慢性腎臓病 / 再生医学 |
Outline of Final Research Achievements |
We deal with the assessment of the protective role of 5-aminolevulinic acid (ALA) in cisplatin-induced acute kidney injury (AKI). Nephrotoxicity is a frequent and major limitation of cisplatin-based chemotherapy. ALA is widely distributed in animal cells and is a precursor of tetrapyrole compounds such as heme, which is fundamentally important in aerobic energy metabolism. We found 2 novel findings: First, ALA ameliorates renal function in cisplatin-induced AKI by protecting mitochondrial enzymes and viability, as well as prevents tubular apoptosis in vivo and in vitro. Second, ALA has no significant effects on the anticancer efficiency of cisplatin in rats. Thus, ALA has the potential to prevent cisplatin-induced nephrotoxicity without compromising the anticancer efficacy of cisplatin.
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Free Research Field |
腎臓内科
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