2014 Fiscal Year Final Research Report
Challenge for neutralizing antibody theory: Vaccine development specific to Abeta oligomers
| Project/Area Number |
25670415
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | ワクチン |
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| Outline of Final Research Achievements |
It has been well known that Aβ oligomers are synaptotoxic and molecular basis of memory loss, which is candidate molecules for drug development in Alzheimer’s disease. We aimed to develop a novel vaccine targeting Aβ oligomers alone to assess if the appearance of neutralizing antibody against parent one is really problematic or not from therapeutic point of view. It was easy to make neutralizaing antibodies. However, when anti-ideotype antibodies themselves were directly immunized to mouse pad, we can hardly detect anti-ideotypic antibodies in blood obtained from immunized mice, suggesting that we need to design something like anti-ideotype vaccine to retrieve of in vivo action.
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| Free Research Field |
神経内科学
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