2015 Fiscal Year Final Research Report
Trial to develop oxidative stress erasing therapy to treat Alzheimer disease using redox nanoparticles
| Project/Area Number |
25670416
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Ishii Kazuhiro 筑波大学, 医学医療系, 准教授 (70323293)
Tamaoka Akira 筑波大学, 医学医療系, 教授 (50192183)
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| Co-Investigator(Renkei-kenkyūsha) |
Nagasaki Yukio 筑波大学, 数理物質系, 教授 (90198309)
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| Research Collaborator |
Koide Takuya
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アルツハイマー病 / アミロイド |
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| Outline of Final Research Achievements |
To test the ability for redox nanoparticles therapeutics to suppress the development of dementia in Alzheimer disease patients, redox nanooarticles which have capacity to reduce active oxigen, were administrated to Tg2576 mice. Unfortunately, treated mice did not show improvement in either behavioral, neuropathological or biochemical aspects. However, during the process of the study, as described in the grant application, antibody specific to toxic Abeta conformer was evaluated with synthetic peptides, autopsied Alzheimer brains and CSF in order to use the new antibody for biochemical and immunopathological examinations of the mice. Consequentially, the method to detect toxic Abeta conformer in biological samples was established and new aspects were obtained, which leads us a new insight to develop noble strategy to diagnose and treat Alzheimer disease.
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| Free Research Field |
神経内科学
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