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2014 Fiscal Year Final Research Report

Analyses for extracellular matrix in neuronal stem cell niche of aged brain

Research Project

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Project/Area Number 25670426
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

ARIKAWA-HIRASAWA Eri  順天堂大学, 医学(系)研究科(研究院), 准教授 (50245718)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords成体神経新生 / 細胞外マトリックス / ヘパラン硫酸鎖 / 老化
Outline of Final Research Achievements

The subventricular zone (SVZ) is one of the area for neurogenesis in adult brain. In the SVZ neurogenic niche, specialized extracellular matrix (ECM) structures, fractones contact neural stem cells. We previously showed that heparan sulfate proteoglycan in the fractones regulate the growth factor activity and promote neurogenesis. We analyze the effect of aging on structure of fractones and composition of ECM molecules. Here, we report that fractone size significantly increased but fractone number significantly decreased with aging. Furthermore, we observed that the heparan sulfate chains contained in fractones were changed with aging. These results suggest that the change of morphology and specific composition of sugar chain in fractones may be related to decrease in neurogenesis in the aged SVZ.

Free Research Field

神経内科

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Published: 2016-06-03  

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