2014 Fiscal Year Final Research Report
Analyses for extracellular matrix in neuronal stem cell niche of aged brain
| Project/Area Number |
25670426
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 成体神経新生 / 細胞外マトリックス / ヘパラン硫酸鎖 / 老化 |
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| Outline of Final Research Achievements |
The subventricular zone (SVZ) is one of the area for neurogenesis in adult brain. In the SVZ neurogenic niche, specialized extracellular matrix (ECM) structures, fractones contact neural stem cells. We previously showed that heparan sulfate proteoglycan in the fractones regulate the growth factor activity and promote neurogenesis. We analyze the effect of aging on structure of fractones and composition of ECM molecules. Here, we report that fractone size significantly increased but fractone number significantly decreased with aging. Furthermore, we observed that the heparan sulfate chains contained in fractones were changed with aging. These results suggest that the change of morphology and specific composition of sugar chain in fractones may be related to decrease in neurogenesis in the aged SVZ.
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| Free Research Field |
神経内科
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